The Phoenix Shrine Auditorium (El Zaribah Shrine Center) is located just east of downtown Phoenix - less than 30 minutes from either end of the metro area. At least, when we're meeting in mid-day!
If you're driving from the west (Sun City), take the 202 east to the 40th Street exit. At the exit turn right and you'll see the Shrine Auditorium on your right.
If you're driving from the east (Mesa), take the 60 west until it merges into Interstate 10. Keep right and exit on the 143 (as if you're going to the airport). Continue beyond the airport exit to Van Buren. Exit there and turn left (note: stay in the right hand of the two exit lanes going left). In just a few blocks, turn north (right) onto 40th Street. The Shrine Auditorium will be on your left - there is a center turn lane.