The Phoenix Shrine Auditorium (El Zaribah Shrine Center) is located just east of downtown Phoenix - less than 30 minutes from either end of the metro area. At least, when we're meeting in mid-day!
552 N. 40th Street
Phoenix, AZ 85008
If you're driving from the west (Sun City), take the 202 east to the 40th Street exit. At the exit turn right and you'll see the Shrine Auditorium on your right.
If you're driving from the east (Mesa), take the 60 west until it merges into Interstate 10. Keep right and exit on the 143 (as if you're going to the airport). Continue beyond the airport exit to the Washington Street exit. Exit there and turn left. In just a few blocks, turn north (right) onto 40th Street. Drive north beyond Van Buren. The Shrine Auditorium will be on your left - there is a center turn lane.
Or you can take the 202 westbound to the 44th Street exit. Stay on the frontage road to 40th Street and then turn left (south) and the Shrine Auditorium is a few blocks south.